When viewing a File Resource using Same window With frame, the breadcrumb links in the header frame load into the header, rather than _top - making the breadcrumb links essentially unusable.
This is because the target attribute has been replaced with onclick="this.target='_top'", in pursuit of XHTML compliance - at the cost of extra reliance on javascript, arguably in conflict with WCAG 12.1 Graceful transformation of scripts (http://www.w3.org/TR/WCAG10-HTML-TECHS/#scripts
I'm aware of the Without frame option, but the extra scrollbar which appears with it rather puts me off.
NB: The target attribute is no longer depreciated in HTML5.
(As discussed in http://moodle.org/mod/forum/discuss.php?d=132885)